French national reference center for pulmonary hypertension
The rare diseases reference center treats patients suffering from severe pulmonary hypertension. It is part of a network of 7 reference centers and 22 competence centers.
The pulmonary hypertension reference center at Necker-Enfants malades University hospital is the only pediatric reference center for all types of pulmonary hypertension. These include newborns, children and adolescents.
The Necker pediatric site is equipped with the full range of diagnostic facilities for pulmonary hypertension. It plays an active role in therapeutic innovation in pediatric pulmonary arterial hypertension, coordinating the majority of therapeutic trials in France. It has a full range of techniques for treating the most severe forms, including Potts anastomosis and lung transplantation.
This reference center is affiliated to the RESPIFIL rare diseases healthcare network and the LUNG European reference network (ERN).
Keywords : Pulmonary hypertension, PAH, children, lung transplantation, genetics
Medical
team
Pr Damien Bonnet
MD, PhD
In case of emergency
- Idiopathic pulmonary arterial hypertension
- Heritable pulmonary arterial hypertension
- Pulmonary arterial hypertension associated with congenital heart disease
- Pulmonary arterial hypertension associated with portal hypertension
- Pulmonary arterial hypertension associated with connective tissue disease
- Pulmonary arterial hypertension in the newborn
- Pulmonary veno-occlusive disease
- Pulmonary hypertension of congenital pathologies of the left heart
- Pulmonary hypertension from respiratory diseases in children
- Pulmonary hypertension from multifactorial causes
- Pr Damien Bonnnet, cardiologist: head of the reference center
- Isabelle Szezepanski, clinical research assistant pulmonary hypertension
- Dr Marilyne Lévy, cardiologist : pulmonary hypertension
- Pr Olivier Raisky, cardiac surgery, lung transplantation
Pulmonary arterial hypertension and congenital heart disease in children
Heart failure and congenital heart disease in children
Adolescent-adulthood transition
Cardiac pacemakers and defibrillators in children
Antivitamin K in children
- Univentricular heart disease (2022)
- Atrioventricular canal (2022)
- Pulmonary arterial hypertension (2020)
- RASopathies: Noonan, cardio-facio-cutaneous and related syndromes (2016)
- Williams and Beuren syndrome (2014)
- Transposition of the great vessels (2008)
- Tetralogy of Fallot (2008)
- Common arterial trunk (2008)
- Congenital heart diseases Itinerair register : epidemiology and care of pulmonary hypertension in congenital heart diseases
- TOPP international register
- Genetics of pulmonary hypertensions in children
- Treprostinil, selexipag, sotatercept therapeutic trials
- Pulmonary hypertension with venous component
University diploma in pediatric cardiology
University of Paris
Inter-university diploma in congenital and pediatric cardiology
University of Paris, Lille II university and university of Lyon
Inter-university diploma in surgical resuscitation of congenital heart disease
University of Paris and Bordeaux II university
Inter-university diploma in congenital heart disease surgery
University of Paris, university of Bordeaux, university of Marseille and university of Lyon
2024
– Application of a modified clinical classification for pulmonary arterial hypertension associated with congenital heart disease in children: emphasis on atrial septal defects and transposition of the great arteries. An analysis from the TOPP registry.
Wacker J, Humpl T, Berger RMF, Ivy D, Bowers D, Bonnet D, Beghetti M.
Front Cardiovasc Med. 2024 Feb 2;11:1344014. doi: 10.3389/fcvm.2024.1344014. PMID: 38370158; PMCID: PMC10870771.
2023
– Monitoring of Hemodynamics With Right Heart Catheterization in Children With Pulmonary Arterial Hypertension.
Grynblat J, Malekzadeh-Milani SG, Meot M, Perros F, Szezepanski I, Morisset S, Ovaert C, Bonnet C, Maragnes P, Ranchoup J, Humbert M, Montani ID, Levy M, Bonnet D.
J Am Heart Assoc. 2023 Apr 4;12(7):e029085.
– Long-term Outcome of Children with Newly Diagnosed Pulmonary Arterial Hypertension: Results From the Global TOPP-registry.
Ploegstra MJ, Ivy DD, Beghetti M, Bonnet D, Alehan D, Ablonczy L, Mattos S, Bowers D, Humpl T, Berger RMF; TOPP Investigators.
Eur Heart J Qual Care Clin Outcomes. 2023 Mar 27:qcad020.
2017
– Safety and Feasibility of the Transcatheter Approach to Create a Reverse Potts Shunt in Children With Idiopathic Pulmonary Arterial Hypertension.
Boudjemline Y, Sizarov A, Malekzadeh-Milani S, Mirabile C, Lenoir M, Khraiche D, Lévy M, Bonnet D.
Can J Cardiol 2017;33:1188-1196.
2016
– Growth in children with pulmonary arterial hypertension: a longitudinal retrospective multiregistry study.
Ploegstra MJ, Ivy DD, Wheeler JG, Brand M, Beghetti M, Rosenzweig EB, Humpl T, Iriart X, Rouzic EM, Bonnet D, Berger RM.
Lancet Respir Med 2016 ; 4:281-90.
– To « Cath » or Not in Pediatric Pulmonary Hypertension?
Beghetti M, Berger RM, Ivy DD, Bonnet D, Humpl T.
J Am Coll Cardiol 2016;67:1010-1.
– Executive summary. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK.
Hansmann G, Apitz C, Abdul-Khaliq H, Alastalo TP, Beerbaum P, Bonnet D, Dubowy KO, Gorenflo M, Hager A, Hilgendorff A, Kaestner M, Koestenberger M, Koskenvuo JW, Kozlik-Feldmann R, Kuehne T, Lammers AE, Latus H, Michel-Behnke I, Miera O, Moledina S, Muthurangu V, Pattathu J, Schranz D, Warnecke G, Zartner P.
Heart 2016;102 Suppl 2:ii86-ii100.
– Genetic analyses in a cohort of children with pulmonary hypertension.
Levy M, Eyries M, Szezepanski I, Ladouceur M, Nadaud S, Bonnet D, Soubrier F.
Eur Respir J 2016 ;48 :1118-1126.
Contact information
Necker-Enfants malades university hospital
> Cardiology department
149 rue de Sèvres
75743 PARIS Cedex 15
In Necker, the reference center for pulmonary hypertension in brief …
* data valid for 2022